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Historic NY

(39,470 posts) Sat Nov 8, 2025, 11:53 AM Saturday

Scientists have edited a gene that may reduce high cholesterol permanently

The study was extremely small — only 15 patients with severe disease — and was meant to test the safety of a new medication delivered by CRISPR-Cas9, a biological sort of scissor which cuts a targeted gene to modify or turn it on or off.

Preliminary results, however, showed nearly a 50% reduction in low-density lipoprotein, or LDL, the “bad” cholesterol which plays a major role in heart disease — the No.1 killer of adults in the United States and worldwide.

https://www.cnn.com/2025/11/08/health/cholesterol-gene-edit-wellness]

4 replies

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Scientists have edited a gene that may reduce high cholesterol permanently (Original Post) Historic NY Saturday OP

No normal adult is ever going to have LDL of 40 or 50 Justice Brandeis Saturday #1

Interesting- a Korean study in major Med journal (nature.com) womanofthehills Saturday #4

No doubt the tRump HHS department.... MyOwnPeace Saturday #2

Please keep this hidden, until TSF bluestarone Saturday #3

Justice Brandeis

(382 posts)

1. No normal adult is ever going to have LDL of 40 or 50

Reply to Historic NY (Original post)

Sat Nov 8, 2025, 12:11 PM

Saturday

The low 100's is far more realistic.

womanofthehills

(10,604 posts)

4. Interesting- a Korean study in major Med journal (nature.com)

Reply to Justice Brandeis (Reply #1)

Sat Nov 8, 2025, 01:03 PM

Saturday

Of the entire population of Korea - study claimed “older” Koreans with cholesterol of 210 to 249 lived the longest. So many contradictions in this world!!! I’m sure there are studies with contradictions but being my cholesterol is 220 - I’m going with this one. 🙃.

“Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults”

TC levels associated with lowest mortality were 210-249 mg/dL, except for men aged 18-34 years (180-219 mg/dL) and women aged 18-34 years (160-199 mg/dL) and 35-44 years (180-219 mg/dL). The inverse associations for TC < 200 mg/dL were stronger than the positive associations in the upper range.

https://www.nature.com/articles/s41598-018-38461-y

https://pubmed.ncbi.nlm.nih.gov/30733566/

MyOwnPeace

(17,412 posts)

2. No doubt the tRump HHS department....

Reply to Historic NY (Original post)

Sat Nov 8, 2025, 12:44 PM

Saturday

will cut funding for any research related to this. We can't have 'progress' in health care, can we............

bluestarone

(20,756 posts)

3. Please keep this hidden, until TSF

Reply to Historic NY (Original post)

Sat Nov 8, 2025, 12:49 PM

Saturday

is long gone!!

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