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PCIntern

(27,791 posts)
Sat Nov 8, 2025, 07:33 PM Saturday

You know, this is a distinct possibility given the evidence:

Severe, Intolerable Fatigue Associated with Hyperresponse to Clopidogrel

Author links open overlay panel
David I. Bass Christopher C. Young Min S. Park Michael J. Cruz Kate T. Carroll Kevin N. Vanent Chungeun Lee Rajeev D. Sen Dominick J. Angiolillo 5, Marco Cattaneo 6, Louis J. Kim 1 7 8, Michael R. Levitt

https://doi.org/10.1016/j.wneu.2021.09.075

Objective
Clopidogrel is a commonly used antiplatelet agent for the prevention of thromboembolic complications following neuroendovascular procedures, but anecdotal data have raised concern for the possibility that clopidogrel may induce severe, intolerable fatigue. The purpose of this study is to systematically investigate this phenomenon.

***************
Conclusions
A syndrome of severe fatigue and other constitutional symptoms is a rare but clinically significant side effect of hyperresponse to clopidogrel in patients undergoing neuroendovasular intervention.


Kud bee……or similar meds prescribed for similar purposes. Several different types of hypertensive drugs, cause exhaustion, including beta blockers.

22 replies = new reply since forum marked as read
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You know, this is a distinct possibility given the evidence: (Original Post) PCIntern Saturday OP
Perhaps you're thinking that this drug might be causing him to fall asleep in meetings? CaliforniaPeggy Saturday #1
Would this make flying more dangerous for him? IcyPeas Saturday #2
Could this slow him down dweller Saturday #3
That's a possibility and a good fit bucolic_frolic Saturday #4
It appears they are doing what they can to keep him cachukis Saturday #5
Neuroendovascular procedures? Minimally invasive brain surgery? tinrobot Saturday #6
Not necessarily surgery. Been taking that drug since my TIA stroke... Wounded Bear Saturday #7
Happy to hear that about you personally... PCIntern Saturday #8
Indeed. Can't imagine all he's probably on to keep him upright...nt Wounded Bear Saturday #9
I can speak to this personally. Prairie_Seagull Sunday #22
I've been on that since my AAA repair roughly 18 months ago. Gore1FL Saturday #10
He's old, tired, and his brain is failing him babylonsister Saturday #11
He was falling asleep in the courtroom ages ago, though buzzycrumbhunger Saturday #12
It's common enough that they did study on it PCIntern Saturday #16
Correlation doesn't equal causation sakabatou Saturday #13
Guess what... PCIntern Saturday #15
Can't be this. llmart Saturday #14
Sleepness is also caused by staying up all night posting trolling bullshit. Swede Saturday #17
I wonder if canetoad Saturday #18
I think he's got so many comorbidities... buzzycrumbhunger Sunday #19
That looks real bad! You'd think that idiot doc of his could do something about it. CTyankee Sunday #20
Biff Spraytannen is mellowing like a... Hugin Sunday #21

CaliforniaPeggy

(155,704 posts)
1. Perhaps you're thinking that this drug might be causing him to fall asleep in meetings?
Sat Nov 8, 2025, 07:39 PM
Saturday

Could be.



bucolic_frolic

(53,228 posts)
4. That's a possibility and a good fit
Sat Nov 8, 2025, 07:48 PM
Saturday

Lots of treatments cause fatigue. That "washed-out" feeling: IV chelation. Droopy confusion: Anti-psychotics.

tinrobot

(11,870 posts)
6. Neuroendovascular procedures? Minimally invasive brain surgery?
Sat Nov 8, 2025, 07:53 PM
Saturday

I'm surprised they found a brain.

Seriously, if he had brain surgery, that needs to be disclosed.

Wounded Bear

(63,486 posts)
7. Not necessarily surgery. Been taking that drug since my TIA stroke...
Sat Nov 8, 2025, 07:56 PM
Saturday

Haven't had that symptom so far and it's been several months.

PCIntern

(27,791 posts)
8. Happy to hear that about you personally...
Sat Nov 8, 2025, 07:59 PM
Saturday

It could be in combination with other medication he’s taking including beta blockers and who knows what else?

Prairie_Seagull

(4,552 posts)
22. I can speak to this personally.
Sun Nov 9, 2025, 10:33 AM
Sunday

I have contacted all of my docs about this and the response I get is, the fatigue is probably associated with something else. Like type 2 diabetes.

Without it however I am prone to significant TIA's. To the point where I really no longer go to the hospital. What would be another medication option?

I will be pointing to this study with a doc in near future.

Gore1FL

(22,737 posts)
10. I've been on that since my AAA repair roughly 18 months ago.
Sat Nov 8, 2025, 08:12 PM
Saturday

I'm always tired, but assume it has to do with my poor sleep habits and outcomes.

buzzycrumbhunger

(1,470 posts)
12. He was falling asleep in the courtroom ages ago, though
Sat Nov 8, 2025, 09:09 PM
Saturday

I suppose clopidogrel could be a factor, though in my time as a pharmacy tech, we dispense tons of this and I’ve never seen a patient with that complaint. I think it’s likely multifactorial, beginning with the fact he’s OLD, has fecal and urinary incompetence, the frontotemporal dementia, probable escalating tertiary syphilis, and has been popping Adderall and other crap as he pleases, eats McDonald’s garbage in huge quantities, yada, yada, yada.

I think it’s not unlikely that a new medication regime could indeed be one thing too many on top of all his other problems. If so, I vote that they double the dose and hurry him over the precipice.

PCIntern

(27,791 posts)
16. It's common enough that they did study on it
Sat Nov 8, 2025, 09:50 PM
Saturday

And furthermore, who knows what else he’s on at this could be interacting with? Anything is possible, considering that he has possibly not had the best advice or necessarily heeds any competent physician’s advice.

sakabatou

(45,518 posts)
13. Correlation doesn't equal causation
Sat Nov 8, 2025, 09:24 PM
Saturday

While his napping could be chalked up to his health, we shouldn't come to a hasty conclusion.

PCIntern

(27,791 posts)
15. Guess what...
Sat Nov 8, 2025, 09:48 PM
Saturday

I can do anything I please. I can come to any conclusion I want given they feed us no information and there’s obviously a big problem. I can think he had a stroke, I can think he is on too many medications for his own good, I can think that they’re being implanted in his food by the CIA.

Ain’t no hasty conclusions here. I’ve been watching this sociopath for 40 years. Anything I say is valid as anything anybody else says and try to prove me wrong.

llmart

(17,067 posts)
14. Can't be this.
Sat Nov 8, 2025, 09:27 PM
Saturday

He shows no "constitutional symptoms". He shits on our constitution every day.

buzzycrumbhunger

(1,470 posts)
19. I think he's got so many comorbidities...
Sun Nov 9, 2025, 10:14 AM
Sunday

... that it might not be possible to blame one thing.

But hey, he's obviously getting worse so we all might have a happy Thanksgiving. Keep a good thought! 😉

CTyankee

(67,537 posts)
20. That looks real bad! You'd think that idiot doc of his could do something about it.
Sun Nov 9, 2025, 10:20 AM
Sunday

What does this swelling indicate?

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