Countries in the Persian Gulf shut down their airspace, forcing some of the world’s biggest airlines to halt operations after Iran targeted US bases across the peninsula in retaliatory strikes.

Emirates, the world’s largest international airline, suspended all flight operations to and from Dubai, citing “multiple regional airspace closures.” The Qatari civil aviation authority said that the airspace over the country has been temporarily closed, effectively halting operations of Qatar Airways, among the biggest international carriers.

All Emirates flights are canceled till 3 am on Sunday, according to the airline’s hub, Dubai International Airport. The disruption for such a large part of the airspace over the Gulf is unprecedented and has resulted in the cancellation of hundreds of flights in some of the world’s most active airports.

The United Arab Emirates and Kuwait, which were among the countries targeted, also closed their airspaces in reaction to missile attacks from Iran. The majority of international airlines have canceled flights to the Gulf and carriers in India have also cut back their services.