Science
Related: About this forummRNA vaccines show promise in pancreatic cancer in early trial
NBC
Feb. 19, 2025, 11:22 AM EST
By Kaitlin Sullivan
Personalized mRNA vaccines show promise as pancreatic cancer treatment, a phase 1 clinical trial published Wednesday in Nature found.
Fewer than 13% of people diagnosed with pancreatic cancer live for more than five years, making it one of the deadliest types of cancer. That is, in part, because around 90% of cases are diagnosed when the disease is already advanced.
Pancreatic cancer cells also spread to other parts of the body much earlier on than in other cancers, which typically spread only when the original tumors are large. The disease typically doesnt cause symptoms until later stages and there isnt a routine screening for this cancer, such as a mammogram or colonoscopy.
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To be effective, mRNA cancer vaccines have to produce a lot of T cells, a type of immune cell that protects the body against invaders. These T cells also need to last a long time in cancer patients and retain their ability to detect and fight off cancer cells. While this is a relatively straightforward feat when it comes to viruses, teaching a persons T cells to fight nonforeign cells that their body itself made is much more difficult.
https://www.nbcnews.com/health/cancer/pancreatic-cancer-vaccine-mrna-treatment-trial-rcna192702

SCantiGOP
(14,377 posts)would be if an effective vaccine for cancer is developed. See if their hesitancy will extend to avoiding that, since every one in the country has known multiple people who have died of cancer.
bucolic_frolic
(49,174 posts)though an actual treatment is a good hurdle, even if it probably costs hundreds of thousands of dollars. As a side note they should pass a law to rush breakthrough treatments through the pipeline at cost and worry about profits later .... but I digress.
We added seed oils in the 1870s. We already were consuming tobacco and impure heavy metals in water and sugar. Then by WWII we added trans fats, more sugar, and more alcohol. And lots of dairy products with refrigeration, and synthetic dyes. Then in the 1970s we added new wheat strains, microwave foods, not to mention pesticides, growth hormones, agribusiness production methods that prevent exercised healthy animals.
Is it any wonder we have diseases of the gut? Because that's what pancreatic cancer is. As is pancreatitis, gallstones, irritable bowel syndrome and its evil twin IB disease, Crohn's disease, celiac disease.
We are flooded with heavily processed food ingredients, toxins, chemicals. And we have a cancer wave. Did we have all these diseases 200 years ago? How would we know, they all died before age 70 of other causes.
Ever notice how thin people who undereat often live to more than 100?