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The Most Detailed Map of the Human Cell Ever Made - Powered by AI and Imaging
https://scitechdaily.com/the-most-detailed-map-of-the-human-cell-ever-made-powered-by-ai-and-imaging/For the first time, scientists have built a detailed, interactive map of a human cell, revealing how thousands of proteins organize and work together.
Using advanced imaging and AI tools like GPT-4, they uncovered hundreds of previously unknown protein functions and identified key cellular assemblies tied to childhood cancers. This map not only changes how we study cell biology but could also transform our understanding of disease at the molecular level.
Mapping the Human Cell: A 400-Year Quest
Scientists have been trying to map the human cell ever since the invention of the microscope more than 400 years ago. Yet, many parts of the cell remain largely unexplored.
“ We know each of the proteins that exist in our cells, but how they fit together to then carry out the function of a cell still remains largely unknown across cell types,” said Leah Schaffer, Ph.D., a postdoctoral research scholar at UC San Diego School of Medicine.
A New Cellular Atlas Emerges
Now, Schaffer and her team at UC San Diego, along with collaborators from Stanford University, Harvard Medical School, and the University of British Columbia, have created a detailed, interactive map of U2OS cells — cells linked to pediatric bone tumors. By combining high-resolution microscopy with data on protein-protein interactions, the researchers mapped the internal structure and organization of proteins within these cells.
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Scientists have been trying to map the human cell ever since the invention of the microscope more than 400 years ago. Yet, many parts of the cell remain largely unexplored.
“ We know each of the proteins that exist in our cells, but how they fit together to then carry out the function of a cell still remains largely unknown across cell types,” said Leah Schaffer, Ph.D., a postdoctoral research scholar at UC San Diego School of Medicine.
A New Cellular Atlas Emerges
Now, Schaffer and her team at UC San Diego, along with collaborators from Stanford University, Harvard Medical School, and the University of British Columbia, have created a detailed, interactive map of U2OS cells — cells linked to pediatric bone tumors. By combining high-resolution microscopy with data on protein-protein interactions, the researchers mapped the internal structure and organization of proteins within these cells.
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