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eppur_se_muova

(39,753 posts)

43. All metazoans -- no viruses. Mechanism of action involves neurotrasmitters, which viruses do not have.

Thu Jul 24, 2025, 02:56 AM

Jul 24

It is effective against a wide range of parasites, including gastrointestinal roundworms, lungworms, mites, lice and hornflies.7–12) Ivermectin is also highly effective against ticks, for example, the ixodid tick Rhipicephalus (Boophilus) microplus, one of the most important cattle parasites in the tropics and subtropics, which causes enormous economic damage.

https://pmc.ncbi.nlm.nih.gov/articles/PMC3043740/

Mode of action

Initially, researchers working on the development of ivermectin believed that it blocked neurotransmitters, acting on GABA-gated Cl- channels, exhibiting potent disruption at GABA receptors in invertebrates and mammals. GABA is recognised as the primary inhibitory neurotransmitter in the somatic neuromuscular system of nematodes. Subsequently, they discovered that it was in fact glutamate-gated Cl- channels (GUCl- ) that were the target of ivermectin and related drugs. This discovery opened up a completely new spectrum of possibilities, as these channels, although playing fundamental roles in nematodes and insects, are not accessible in vertebrates.41–43) Ivermectin, while paralyzing body-wall and pharyngeal muscle in nematodes has no such impact in mammals, as it cannot cross the blood-brain barrier into the mammalian Central Nervous System, where GABA receptors are located.

https://pmc.ncbi.nlm.nih.gov/articles/PMC3043740/#sec7

Interesting to read that it really is a wonder drug where invertebrate infections are involved, but the wonder is sharply limited. No action against vertebrates, or (evidently) against viruses.

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Ken Dayenu

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These States Now Allow OTC Ivermectin, and More May Follow [View all] lostincalifornia Jul 23 OP

I just knew NJCher Jul 23 #1

I was worried it would be Iowa where I am a work hostage JT45242 Jul 23 #6

YEP Cosmocat Jul 23 #7

Gut medicaid, medicare, vaccines. Let people treat themselves with worthless OTC drugs. Irish_Dem Jul 23 #2

I agree. My evangelical nitwit brother is using ivermectin for prostate cancer travelingthrulife Jul 23 #9

Yes cancer is much more treatable in early stages. Irish_Dem Jul 23 #12

I knew someone who got a rare GI cancer. milestogo Jul 23 #16

Well if someone is terminal with no hope, and eating grapes makes them happy, go for it. :( Irish_Dem Jul 23 #17

She just hated western medicine and didn't want to go through chemo. milestogo Jul 23 #18

A friend of mine chose not to go through chemo. Irish_Dem Jul 23 #20

I have Rebl2 Jul 23 #21

I'm sorry Rebl2. That must be hard. milestogo Jul 23 #22

I was Rebl2 Jul 23 #24

I can sympathize. Irish_Dem Jul 23 #23

Same here Rebl2 Jul 23 #26

Remember Sarah Palin and "Death Panels" regarding the ACA? ProudMNDemocrat Jul 24 #45

The GOP always accuses others of the crimes they themselves commit. Irish_Dem Jul 24 #46

Post removed Post removed Jul 24 #48

Under Braun, Delphinus Jul 23 #3

So what? TnDem Jul 23 #4

WTF Skittles Jul 23 #5

OK, but TnDem Jul 23 #37

OMFG Skittles Jul 23 #38

Sorry, don't see the outrage? TnDem Jul 23 #41

Yeah I agree let them have Ivermectin if they want it it'll help get rid of the people we need to be rid of Fullduplexxx Jul 23 #8

See post 9 NJCher Jul 23 #13

Also post 10. nt Wednesdays Jul 23 #19

OK, and read the last line of the post TnDem Jul 23 #36

Worth repeating this story Johnny2X2X Jul 23 #10

I'm all for it: Darwin's Law PCIntern Jul 23 #11

They could always get it at any animal feed store or shipped direct from Amazon Arazi Jul 23 #14

Are they buying it for livestock? milestogo Jul 23 #15

Oh, fantastic, because when I think of public health strategy Torchlight Jul 23 #25

Natural JustAnotherGen Jul 23 #27

Ivermectin can cause death with overdose Blue Full Moon Jul 23 #28

So can Tylenol pcdb Jul 23 #40

And bleach. Torchlight Jul 24 #49

Ivermectin has proven to be a pretty save drug womanofthehills Jul 23 #42

Do they know that a potential side effect of ivermectin is explosive diarrhea? Ritabert Jul 23 #29

This message was self-deleted by its author Ken Dayenu Jul 23 #31

Whatever Ritabert Jul 23 #35

Message auto-removed Name removed Jul 24 #50

All metazoans -- no viruses. Mechanism of action involves neurotrasmitters, which viruses do not have. eppur_se_muova Jul 24 #43

This message was self-deleted by its author Ken Dayenu Jul 24 #44

Yep, acts by disrupting the formation of the cross-linked polysaccharide cell walls of bacteria. eppur_se_muova Jul 24 #47

Well, i'm betting that 100% of Democrats will NEVER take this pill. So bluestarone Jul 23 #30

The topical version, selamectin, is in my cat's flea treatment Walleye Jul 23 #32

My husband uses a prescription ivermectin cream for rosacea Freddie Jul 23 #33

The Republican Party: Promoting Natural Selection for fifty years while denying it exists. Midnight Writer Jul 23 #34

Dipshit MAGAs taking flea and tick medicine. Greybnk48 Jul 23 #39

Ivermectin is an anti-parasitic. Aristus Jul 24 #51

LOL they're culling their herd Faux pas Jul 24 #52