Long shot here...Save popup screen every time I open excel or Word [View all]

I am using a somewhat new computer and have very little on it at all. But I am working with about 15 excel files that I need to access. When I open a file, a separate screen pops up and it's the SAVE or CANCEL choice only. However, you can't save or close and there's no save as choice. You can't x out of it. All you can do to end it is use the Task Manager .

Same thing happens in word. And I can see the document but I can't click on it.

Coworker thought it might be something to do with One Drive and we disabled that, but it still happens and my files are on the computer, not onedrive.

I downloaded a brand new version of Malwarebytes and the system seems clean.

The only thing I remember doing prior to this was use PrintScreen.

I googled and have tried the usual see if there are any stuck keys and everything else looks normal.

Any thoughts of what could make this happen?