Even though you haven't seen much of the manic attacks in her, it could still benefit in some way. Depakote is a mood stabilizer by the way, kind of like lithium. You have to check her blood once and awhile to see if the depakote levels are okay. So yes, keep her close by when you start doing this. I take the "It doesn't hurt until you see." method with pills. I only don't trust two pills in general though.
1. Zyprexa.
My husbands best friend for 35 years took this pill and it gave him type 1 diabetes. There was a class action lawsuit, he got $90,000 in compensation. He then eventually died. He went to the hospital because he didn't feel good, they found out he had pneumonia and some diabetic shock, and he threw up and it went into his lungs... so they put a tube down his throat to help him breathe. He then had a heart attack for 30 minutes and went brain dead from the lack of oxygen going to his brain... That's what we can piece together anyways, we get details mixed up. We blame his wife for neglect, but of course you can't prove it. It was very obvious that he had difficulty taking care of himself, besides staying up all night to roam Chicago, taking thousands of pictures. He'd go about once and awhile claiming he cured himself of diabetes and went to a bar to drink beer... His wife decided to spend time at her mansion out in the middle of no where, to take care of the horses instead of him. She also cashed out on both of the houses they had and was married again within 5 months. There's a lot of other obvious details, but you get the picture.
2. Paxil.
That was the first anti-depressant drug recommended by a doctor to me... except it was by a non-psychiatrist. And I heard you could lose your imagination by taking it. Nooo thanks. I need that. I'm an artist and a writer.
Now, as far as taking her off the pills. NO. Not unless she's in psychward over seen by a doctor. The reason I'm saying this is because I did go off all my medicine before. I was forced to because I over dosed on IBprofin... The pill Lexapro is serious evidence for me that I'm truly bipolar. The only reason I would have that strong of a reaction to it, would be if I was bipolar. It made my manic episodes happen every night almost, and they made them 100x worse. I told them about it, and they upped my lexapro. I went goofy after that... Going off all my pills completely? Aaaaaaahhhhhh... That is pain. It is very painful also because you realize it's not the pills fucking you up necessarily. I mean, I was fucked up...but lexapro only made it worse, and going off of it didn't make things better. It just made things a bit less horrible. But that's it. Plus, you don't know how much is actually working for her... My psychiatrist figured out I was Bipolar II before he died. Turned out he had cancer and didn't tell any of his patients.