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hlthe2b

(110,661 posts)
1. The problem is that Librela is used more as a last resort drug for dogs with advanced OA in the US...
Wed Feb 5, 2025, 10:13 PM
Feb 2025

rather than even a second-line approach in earlier osteoarthritis. In advanced OA, the damage is there and all the pain relief in the world is not going to stop its advancing. Muscle tremors, weakness, lethargy--are all typical in dogs with such advanced OA that euthanasia is the end result--just as wheel-chair and bed confinement is for humans at end stage--after all the surgeries and pain relief no longer help. That doesn't mean it can't help with the pain of osteoarthritis--just that it can't work indefinitely for the most advanced stages.

In epidemiological observational studies, this is known as uncontrolled confounding factors. Like the VAERS system--the observational reporting system for human vaccine reactions, this data is not validated in its raw form, so there can be a lot of alternative reasons for the outcome or (with vaccines), reported 'reactions' .

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