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Science

In reply to the discussion: Science apologizes. [View all]

NNadir

(36,183 posts)
7. Here's the Uniprot reference.
Sat Nov 19, 2022, 02:45 PM
Nov 2022
Q71RS6 · NCKX5_HUMAN

I'm not sure if it lists both isoforms, the ancestral gene or the mutation that makes people white. I have some references somewhere in my files, but I don't have time to find them. As I recall, melanin synthesis proceeds through polymerization of indole derived from tryptophan, but don't quote me on that, I'm working on memory.

Uniprot doesn't seem to list the mutation making people white as a genetic disease, but it does raise the risk of melanoma. In this sense, black skin has a protective effect.

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